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2,5-Bis(trifluoromethyl)aniline
- Name:2,5-Bis(trifluoromethyl)aniline
- CAS:328-93-8
- Purity:99%
Details
Reliable factory customized supply 2,5-Bis(trifluoromethyl)aniline 328-93-8
- Molecular Formula:C8H5F6N
- Molecular Weight:229.125
- Appearance/Colour:Colorless or pale yellow liquid
- Vapor Pressure:0mmHg at 25°C
- Refractive Index:n20/D 1.432(lit.)
- Boiling Point:177.9 °C at 760 mmHg
- PKA:0.24±0.10(Predicted)
- Flash Point:83.3 °C
- PSA：26.02000
- Density:1.443 g/cm3
- LogP:3.88760
2,5-Bis(trifluoromethyl)aniline(Cas 328-93-8) Usage
InChI:InChI=1/C6H5BClFO2/c8-5-1-4(7(10)11)2-6(9)3-5/h1-3,10-11H
328-93-8 Relevant articles
Coordinating Activation Strategy-Induced Selective C?H Trifluoromethylation of Anilines
Xu, Jun,Cheng, Ke,Shen, Chao,Bai, Renren,Xie, Yuanyuan,Zhang, Pengfei
, p. 965 - 970 (2018/02/12)
A simple protocol for the synthesis of 2...
HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF
-
, (2011/12/14)
Provided herein are heteroaryl compounds...
PROCESS FOR PRODUCING 2,5-BIS(TRIFLUOROMETHYL)NITROBENZENE
-
Page 6, (2008/06/13)
A process to produce 2,5-bis(trifluorome...
328-93-8 Process route
-
-
320-88-7
1,4-Bis(trifluoromethyl)-2-nitro-benzene
-
-
328-93-8
2,5-bis(trifluoromethyl)aniline
| Conditions | Yield |
|---|---|
|
With
hydrogen; nickel;
In
isopropyl alcohol;
at 70 - 90 ℃;
for 8h;
under 3677.86 Torr;
|
73% |
|
With
hydrogenchloride; tin(ll) chloride;
|
|
|
1,4-Bis(trifluoromethyl)-2-nitro-benzene;
With
hydrogenchloride; tin(II) chloride dihdyrate;
In
methanol; water;
at 20 - 50 ℃;
With
sodium hydroxide;
In
water;
pH=10;
|
-
-
433-19-2
1,4-bis(trifluoromethyl)benzene
-
-
328-93-8
2,5-bis(trifluoromethyl)aniline
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 2 steps
1: disulfuric acid; sulfuric acid; nitric acid
2: SnCl2+2H2O; concentrated HCl
With
hydrogenchloride; sulfuric acid; nitric acid; disulfuric acid; tin(ll) chloride;
|
|
|
Multi-step reaction with 2 steps
1.1: nitric acid; sulfuric acid / 0 - 110 °C
2.1: hydrogenchloride; tin(II) chloride dihdyrate / water; methanol / 20 - 50 °C
2.2: pH 10
With
hydrogenchloride; tin(II) chloride dihdyrate; sulfuric acid; nitric acid;
In
methanol; water;
|
|
|
durch Nitrierung und Reduktion;
|
328-93-8 Upstream products
-
433-19-2
1,4-bis(trifluoromethyl)benzene
-
328-91-6
2-chloro 1,4-bis(trifluoromethyl)benzene
-
320-88-7
1,4-Bis(trifluoromethyl)-2-nitro-benzene
-
10388-10-0
2-chloro-1,4-bis-(trichloromethyl)-benzene
328-93-8 Downstream products
-
328-92-7
2-iodo-1,4-bis-(trifluoromethyl)-benzene
-
147218-05-1
2,5-bis(trifluoromethyl)-N-<1-<4-(trifluoromethyl)phenyl>ethylidene>aniline
-
147218-04-0
N-<1-(2-fluorophenyl)ethylidene>-2,5-bis(trifluoromethyl)aniline
-
17128-21-1
4-Dimethylamino-2',5'-bis-trifluormethyl-azobenzol
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