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Details
Reliable Quality (S)-(+)-2-PHENYLBUTYRIC ACID 4286-15-1 Hot Sale with Chinese Manufacturer
- Molecular Formula:C10H12 O2
- Molecular Weight:164.204
- Vapor Pressure:0.00288mmHg at 25°C
- Refractive Index:n20/D 1.516(lit.)
- Boiling Point:272.9 ºC at 760 mmHg
- PKA:4.34±0.10(Predicted)
- Flash Point:170.2 ºC
- PSA：37.30000
- Density:1.09 g/cm3
- LogP:2.26480
(S)-(+)-2-PHENYLBUTYRIC ACID(Cas 4286-15-1) Usage
|
Purification Methods |
Purify the acids by distillation at atmospheric pressure using an efficient column. The acid chlorides have b 106-107o/20mm, []D () and (+) 108o (c 2, *C6H6). [Levene et al. J Biol Chem 100 589 1933, Gold & Aubert Helv Chim Acta 41 1512 1958, ORD in heptane: Rothen & Levene J Chem Phys 7 975 1939, Beilstein 9 III 2461.] |
InChI:InChI=1/C10H12O2/c1-2-9(10(11)12)8-6-4-3-5-7-8/h3-7,9H,2H2,1H3,(H,11,12)/t9-/m0/s1
4286-15-1 Relevant articles
Enantioselective α-alkylation of phenylacetic acid using a chiral bidentate lithium amide as a chiral auxiliary
Matsuo, Jun-Ichi,Koga, Kenji
, p. 2122 - 2124 (1997)
Enantioselective alkylation at the α-pos...
Modeling and optimization of lipase-catalyzed hydrolysis for production of (S)-2-phenylbutyric acid enhanced by hydroxyethyl-β-cyclodextrin
Zhang, Panliang,Cheng, Qing,Xu, Weifeng,Tang, Kewen
, p. 96 - 103 (2019/05/27)
An efficient reactive system was establi...
Deracemizing α-Branched Carboxylic Acids by Catalytic Asymmetric Protonation of Bis-Silyl Ketene Acetals with Water or Methanol
Mandrelli, Francesca,Blond, Aurélie,James, Thomas,Kim, Hyejin,List, Benjamin
, p. 11479 - 11482 (2019/07/18)
We report a highly enantioselective cata...
Substrate evaluation of rhodococcus erythropolis SET1, a nitrile hydrolysing bacterium, demonstrating dual activity strongly dependent on nitrile sub-structure
Coady, Tracey M.,Coffey, Lee V.,O'Reilly, Catherine,Lennon, Claire M.
supporting information, p. 1108 - 1116 (2015/02/19)
Assessment of Rhodococcus erythropolis S...
Entrapment of a chiral cobalt complex within silver: A novel heterogeneous catalyst for asymmetric carboxylation of benzyl bromides with CO2
Yang, Heng-Pan,Yue, Ying-Na,Sun, Qi-Long,Feng, Qiu,Wang, Huan,Lu, Jia-Xing
supporting information, p. 12216 - 12219 (2015/07/27)
A novel way to accommodate heterogeneous...
4286-15-1 Process route
-
-
72289-61-3
phenyl-2 butyrate de p-nitrophenyle
-
-
100-02-7,78813-13-5,89830-32-0
4-nitro-phenol
-
-
4286-15-1
(S)-2-phenylbutyric acid
-
-
938-79-4
(2R)-2-phenylbutanoic acid
| Conditions | Yield |
|---|---|
|
With
Candida antarctica lipase A wild type;
In
acetonitrile;
at 20 ℃;
for 4h;
optical yield given as %ee;
enantioselective reaction;
aq. phosphate buffer;
aq. buffer;
Enzymatic reaction;
|
-
-
(4R)-3-((2S)-2-phenylbutanoyl)-4-phenyl-oxazolidin-2-one
-
-
4286-15-1
(S)-2-phenylbutyric acid
-
-
90319-52-1,7480-32-2
(4R)-phenyl-2-oxazolidinone
| Conditions | Yield |
|---|---|
|
(4R)-3-((2S)-2-phenylbutanoyl)-4-phenyl-oxazolidin-2-one;
With
lithium hydroxide monohydrate; dihydrogen peroxide;
In
tetrahydrofuran; water;
at 20 ℃;
for 12h;
Inert atmosphere;
With
hydrogenchloride;
In
water;
pH=3;
Inert atmosphere;
|
82% 91% |
|
With
dihydrogen peroxide; lithium hydroxide;
In
tetrahydrofuran; water;
|
89% 85% |
4286-15-1 Upstream products
-
2627-86-3
(S)-1-phenyl-ethylamine
-
90-27-7
2-Phenylbutyric acid
-
485-71-2
Cinchonidin
-
6169-06-8
(S)-2-Octanol
4286-15-1 Downstream products
-
64187-99-1
(1S,2'S)-N-<1-(1-naphthyl)ethyl>-2-phenylbutanamide
-
64187-98-0
(1R,2'S)-N-<1-(1-naphthyl)ethyl>-2-phenylbutanamide
-
33442-47-6
(S)-2-phenylbutan-1-ol
-
16460-75-6
(R)-2-phenyl-butan-1-ol
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