2-ETHOXY-5-(4-ETHYLPIPERAZINE-1-SULFONYL]NICOTINIC ACID

  • Name: 2-ETHOXY-5-(4-ETHYLPIPERAZINE-1-SULFONYL]NICOTINIC ACID
  • CAS: 247582-73-6
  • Purity: 99%
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Quality products?make an important contribution to long-term revenue and profitability. Chinese Manufacturer Supply 2-ETHOXY-5-(4-ETHYLPIPERAZINE-1-SULFONYL]NICOTINIC ACID 247582-73-6 On Stock with Competitive Price

1.What is the 2-ETHOXY-5-(4-ETHYLPIPERAZINE-1-SULFONYL]NICOTINIC ACID ?

Used in Pharmaceutical Industry:
2-ETHOXY-5-(4-ETHYLPIPERAZINE-1-SULFONYL)NICOTINIC ACID is used as an anti-inflammatory agent for its ability to selectively antagonize the purinergic P2 receptor, thereby reducing the release of inflammatory mediators. This makes it a potential treatment for various inflammatory conditions.
Used in Autoimmune Disease Treatment:
In the field of autoimmune disease management, 2-ETHOXY-5-(4-ETHYLPIPERAZINE-1-SULFONYL)NICOTINIC ACID is used as a therapeutic agent to alleviate symptoms and potentially modify the disease course in conditions such as rheumatoid arthritis and inflammatory bowel disease, based on its demonstrated effects in preclinical models.
Used in Clinical Research:
2-ETHOXY-5-(4-ETHYLPIPERAZINE-1-SULFONYL)NICOTINIC ACID is utilized as a subject of investigation in clinical trials to explore its potential therapeutic effects and safety in human subjects, with the aim of advancing its application in medical treatments for inflammatory and autoimmune diseases.

2-Ethoxy-5-(4-ethylpiperazin-1-ylsulphonyl)pyridine-3-carboxylic Acid Ethyl Ester
247582-68-9

2-Ethoxy-5-(4-ethylpiperazin-1-ylsulphonyl)pyridine-3-carboxylic Acid Ethyl Ester

2-Ethoxy-5-(4-ethylpiperazin-1-ylsulphonyl)pyridine-3-carboxylic Acid
247582-73-6

2-Ethoxy-5-(4-ethylpiperazin-1-ylsulphonyl)pyridine-3-carboxylic Acid

Conditions
Conditions Yield
With sodium hydroxide; In water; toluene; at 25 ℃; for 10h;
43%
With sodium hydroxide; In water; toluene; at 20 ℃;
With sodium hydroxide; In ethanol; water; at 20 ℃; for 2h;
2-Ethoxy-5-(4-ethylpiperazin-1-ylsulphonyl)pyridine-3-carboxylic Acid Ethyl Ester; With sodium hydroxide; In ethanol; at 20 - 25 ℃; for 2h;
With hydrogenchloride; In diethyl ether; ethanol; water; pH=5;
4.02 g
Ethyl 2-chloro-5-(4-ethyl-1-piperazinylsulfonyl) nicotinoate
334708-08-6

Ethyl 2-chloro-5-(4-ethyl-1-piperazinylsulfonyl) nicotinoate

sodium ethanolate
141-52-6

sodium ethanolate

2-Ethoxy-5-(4-ethylpiperazin-1-ylsulphonyl)pyridine-3-carboxylic Acid
247582-73-6

2-Ethoxy-5-(4-ethylpiperazin-1-ylsulphonyl)pyridine-3-carboxylic Acid

Conditions
Conditions Yield
Ethyl 2-chloro-5-(4-ethyl-1-piperazinylsulfonyl) nicotinoate; sodium ethanolate; In toluene; at 10 - 20 ℃;
With sodium hydroxide; In water; toluene; at 40 ℃; for 18h;
338.4 g

2.What is the CAS number for 2-ETHOXY-5-(4-ETHYLPIPERAZINE-1-SULFONYL]NICOTINIC ACID ?

The CAS number of 2-ETHOXY-5-(4-ETHYLPIPERAZINE-1-SULFONYL]NICOTINIC ACID is 247582-73-6.

More information of 2-ETHOXY-5-(4-ETHYLPIPERAZINE-1-SULFONYL]NICOTINIC ACID 247582-73-6 are:

CAS?Number

247582-73-6

Density

1.322±0.06 g/cm3(Predicted)

Boiling Point

519.1±60.0 °C(Predicted)

PSA

108.42000

LogP

1.46130

Pka

3.06±0.10(Predicted)

3.What are another words for 2-ETHOXY-5-(4-ETHYLPIPERAZINE-1-SULFONYL]NICOTINIC ACID ?

Synonyms?for?2-ETHOXY-5-(4-ETHYLPIPERAZINE-1-SULFONYL]NICOTINIC ACID 247582-73-6:2-Ethoxy-5-(4-ethyl-1-piperazinylsulfonyl)nicotinicacid; 3-Carboxy-2-ethoxy-5-(4-ethylpiperazin-1-ylsulfonyl)pyridine

4.What is the molecular formula of 2-ETHOXY-5-(4-ETHYLPIPERAZINE-1-SULFONYL]NICOTINIC ACID?

The chemical formula of ?2-ETHOXY-5-(4-ETHYLPIPERAZINE-1-SULFONYL]NICOTINIC ACID is?C14 H21 N3 O5 S which containing 14 Carbon atoms,21 Hydrogen atoms,3 Nitrogen atoms,5 Oxygen atoms and 1 Sulfur atoms,and the molecular weight of??2-ETHOXY-5-(4-ETHYLPIPERAZINE-1-SULFONYL]NICOTINIC ACID?is 343.404.

5.What is 2-ETHOXY-5-(4-ETHYLPIPERAZINE-1-SULFONYL]NICOTINIC ACID (247582-73-6) used for?

2-ETHOXY-5-(4-ETHYLPIPERAZINE-1-SULFONYL)NICOTINIC ACID, also known as E5448, is a nicotinic acid derivative with selective antagonistic properties towards the purinergic P2 receptor. This chemical compound has demonstrated its potential in managing inflammatory and autoimmune diseases by inhibiting the release of inflammatory mediators. Its efficacy has been observed in preclinical models, making it a promising candidate for clinical trials aimed at treating conditions such as rheumatoid arthritis and inflammatory bowel disease.

Relevant articles related to 2-ETHOXY-5-(4-ETHYLPIPERAZINE-1-SULFONYL]NICOTINIC ACID:

Article

Source

The discovery of UK-369003, a novel PDE5 inhibitor with the potential for oral bioavailability and dose-proportional pharmacokinetics

Rawson, David J.,Ballard, Stephen,Barber, Christopher,Barker, Laura,Beaumont, Kevin,Bunnage, Mark,Cole, Susan,Corless, Martin,Denton, Stephen,Ellis, David,Floc'H, Marion,Foster, Laura,Gosset, James,Holmwood, Frances,Lane, Charlotte,Leahy, David,Mathias, John,Maw, Graham,Million, William,Poinsard, Cedric,Price, Jenny,Russel, Rachel,Street, Stephen,Watson, Lesa

experimental part, p. 498 - 509 (2012/03/08)

Pyrazolopyrimidine derivatives

-

Page 70, (2010/01/31)

6.Buy 2-ETHOXY-5-(4-ETHYLPIPERAZINE-1-SULFONYL]NICOTINIC ACID with the best price .

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