2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride

  • Name: 2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride
  • CAS: 103577-66-8
  • Purity: 99%
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Cosmetics Grade 2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride 103577-66-8 For Sale with Good Price

  • Molecular Formula: C9H10F3NO2
  • Molecular Weight: 221.179
  • Melting Point: 93-94 °C(Solv: isopropyl ether (108-20-3); hexane (110-54-3)) 
  • Boiling Point: 273.6 °C at 760 mmHg 
  • PKA: 13.17±0.10(Predicted) 
  • Flash Point: 119.3 °C 
  • PSA： 42.35000 
  • Density: 1.303 g/cm3 
  • LogP: 2.62540 

2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride(Cas 103577-66-8) Usage

InChI:InChI=1/C9H10F3NO2.ClH/c1-6-7(4-14)13-3-2-8(6)15-5-9(10,11)12;/h2-3,14H,4-5H2,1H3;1H

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103577-66-8 Process route

2-acetoxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine
112525-75-4

2-acetoxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine

2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine
103577-66-8

2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine

Conditions
Conditions Yield
With sodium hydroxide; In methanol; at 25 ℃; for 2h;
With methanol; sodium hydroxide; water; at 20 - 30 ℃; pH=12.5 - 13.5;
95 - 97 %Chromat.
2,3-dimethyl-4-(2,2,2-trifluoroethoxy)-pyridine N-oxide
103577-61-3

2,3-dimethyl-4-(2,2,2-trifluoroethoxy)-pyridine N-oxide

2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine
103577-66-8

2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine

Conditions
Conditions Yield
With sodium hydroxide; sulfuric acid; acetic anhydride; Yield given. Multistep reaction; 1) 100-120 deg C, 5 h, 2) MeOH, rt, 3 h;
Multi-step reaction with 2 steps
1: AcOH / 120 °C
2: 2N aq. NaOH / methanol / 2 h / 25 °C
With sodium hydroxide; acetic acid; In methanol;
2,3-dimethyl-4-(2,2,2-trifluoroethoxy)-pyridine N-oxide; With sulfuric acid; acetic anhydride; at 110 ℃; for 5h;
With hydrogenchloride; In water; for 2h; Reflux;

103577-66-8 Upstream products

  • 103577-61-3
    103577-61-3

    2,3-dimethyl-4-(2,2,2-trifluoroethoxy)-pyridine N-oxide

  • 112525-75-4
    112525-75-4

    2-acetoxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine

  • 37699-43-7
    37699-43-7

    2,3-dimethyl-4-nitropyridine N-oxide

  • 583-61-9
    583-61-9

    2,3-Lutidine

103577-66-8 Downstream products

  • 128430-66-0
    128430-66-0

    2-(chloromethyl)-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine

  • 103577-40-8
    103577-40-8

    lansoprazole sulfide

  • 103577-45-3
    103577-45-3

    lansoprasole

  • 138530-94-6
    138530-94-6

    (R)-lansoprazole

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