(R)-6-(4-Aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone

  • Name:(R)-6-(4-Aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone
  • CAS:101328-85-2
  • Purity:99%
Inquiry

Details

Factory supply good quality (R)-6-(4-Aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone 101328-85-2 with stock

  • Molecular Formula:C11H13N3O
  • Molecular Weight:203.244
  • Appearance/Colour:Pale yellow solid 
  • Melting Point:206-208 °C 
  • Refractive Index:1.653 
  • PKA:13.90±0.60(Predicted) 
  • PSA：67.48000 
  • Density:1.309 g/cm3 
  • LogP:1.47450 

(R)-6-(4-Aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone(Cas 101328-85-2) Usage

InChI:InChI=1/C11H13N3O/c1-7-6-10(15)13-14-11(7)8-2-4-9(12)5-3-8/h2-5,7H,6,12H2,1H3,(H,13,15)/t7-/m1/s1

101328-85-2 Relevant articles

Preparation method of important intermediate of levosimendan

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Paragraph 0059; 0075-0077; 0078; 0094-0096, (2020/03/29)

The invention belongs to the field, of s...

DIHYDROPYRIDAZINONES SUBSTITUTED WITH PHENYLUREAS

-

Page/Page column 221, (2018/05/27)

Compounds of formula (I) which are nicot...

Synthesis and anti-congestive heart failure activity of novel levosimendan analogues

Wang, Lisheng,Zhou, Hongxiang,Yang, Bin,Chen, Zhigang,Yang, Hua

experimental part, p. 287 - 292 (2012/06/05)

A series of levosimendan analogues were ...

PROCESS FOR PREPARING LEVOSIMENDAN AND INTERMEDIATES FOR USE IN THE PROCESS

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, (2011/02/24)

In an embodiment, the present invention ...

101328-85-2 Process route

(R)-4-(4-aminophenyl)-3-methyl-4-oxobutyric acid hydrochloride

(R)-4-(4-aminophenyl)-3-methyl-4-oxobutyric acid hydrochloride

OR-1855
36725-28-7,101328-84-1,101328-85-2,107295-33-0

OR-1855

Conditions
Conditions Yield
With hydrazine hydrate; In ethanol; at 72 ℃; for 1h;
97%
6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone
36725-28-7

6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone

OR-1855
36725-28-7,101328-84-1,101328-85-2,107295-33-0

OR-1855

Conditions
Conditions Yield
With diethylamine; In acetonitrile; Resolution of racemate;
44%
6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone; With L-Tartaric acid; In isopropyl alcohol; for 0.5h; Heating; Resolution of racemate;
With potassium carbonate; In water; pH=7 - 8; Resolution of racemate;
In 1,4-dioxane; for 0.5h; Reflux; Resolution of racemate;
8%
Multi-step reaction with 2 steps
1: ethanol; water / 1.5 h / 15 - 65 °C
2: ammonia / water / 0.5 h / 25 - 30 °C / pH 8 - 9
With ammonia; In ethanol; water;

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