NSC 600157

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What is the NSC 600157 ?

NSC 600157 is , while it's Molecular Formula is C15H9 N O2. Used in Research Applications:
NSC 600157 is used as a research tool for studying the role of Bmi1/Ring1A in chromatin remodeling and the polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination. Its ability to inhibit the E3 ubiquitin ligase activity of RNF2 and the Bmi1/RNF2 complex makes it a valuable asset in understanding the underlying mechanisms of gene regulation and chromatin structure.
Used in Cancer Research:
NSC 600157 is used as a potential therapeutic agent in cancer research, particularly in the context of PRC1-mediated processes that may contribute to tumorigenesis. By inhibiting the Bmi1/Ring1A subunits, PRT-4165 may help to disrupt the abnormal chromatin remodeling that can lead to uncontrolled cell growth and the development of cancer.
Used in Drug Development:
NSC 600157 is used as a starting point for the development of new drugs targeting the polycomb repressive complex 1 (PRC1) and its role in various diseases, including cancer. Its ability to inhibit specific ubiquitination processes and disrupt the function of the Bmi1/RNF2 complex makes it a promising candidate for further investigation and optimization in drug discovery efforts.
Used in Epigenetic Studies:
NSC 600157 is used as a compound of interest in epigenetic research, focusing on the role of PRC1 in regulating gene expression and its potential implications in disease development. Understanding the molecular mechanisms by which PRT-4165 inhibits Bmi1/Ring1A and H2A/H2AX ubiquitination can provide insights into the broader field of epigenetics and the potential for targeted therapeutic interventions.

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