TAXIFOLIN 3-O-RHAMNOSIDE

  • Name: TAXIFOLIN 3-O-RHAMNOSIDE
  • CAS: 29838-67-3
  • Purity: 99%
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What is the TAXIFOLIN 3-O-RHAMNOSIDE ?

TAXIFOLIN 3-O-RHAMNOSIDE is White powder, while it's Molecular Formula is C21 H22 O11 . Astilbin displays anti-depressant activity involving monoaminergic neurotransmitters an the BDNF signal pathway. Anti-oxidant.

What is the CAS number for TAXIFOLIN 3-O-RHAMNOSIDE ?

The CAS number of TAXIFOLIN 3-O-RHAMNOSIDE is 29838-67-3.

More information of TAXIFOLIN 3-O-RHAMNOSIDE 29838-67-3 are:

Synonyms

4H-1-Benzopyran-4-one,3-[(6-deoxy-a-L-mannopyranosyl)oxy]-2-(3,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-,(2R-trans)-;Astilbin (6CI,7CI,8CI);Taxifolin 3-O-rhamnoside;Taxifolin3-rhamnoside;

CAS?Number

29838-67-3

Molecular Formula

C21 H22 O11

Molecular Weight

450.399

Density

1.74 g/cm3

Melting Point

180 °C (decomp)

Boiling Point

801.1 °C at 760 mmHg

Flash Point

282.9 °C

HS CODE

29389090

PSA

186.37000

LogP

0.03810

Pka

7.34±0.60(Predicted)

What is TAXIFOLIN 3-O-RHAMNOSIDE (29838-67-3) used for?

Astilbin is a flavonoid that has been found in S. glabra and has diverse biological activities. It inhibits cisplatin-induced increases in apoptosis and accumulation of reactive oxygen species (ROS) in HEK293 cells when used at a concentration of 200 μM. Astilbin (50 mg/kg) increases renal glutathione (GSH) levels and superoxide dismutase (SOD) and catalase activity and reduces serum creatinine and blood urea nitrogen (BUN) levels, renal IL-1β, IL-6, and TNF-α levels, apoptosis in kidney tissue, and kidney injury in a mouse model of cisplatin-induced nephrotoxicity. It reduces loss of dopaminergic neurons in the substantia nigra and increases striatal GSH levels and SOD activity in a mouse model of MPTP-induced Parkinson''s disease when administered at a dose of 50 mg/kg per day. Astilbin also reduces descent time in a pole test and increases traction test score in a mouse model of Parkinson''s disease, indicating reduced motor deficits. It reduces cell viability of MDA-MB-231 and MCF-7 cells (IC50s = 167.9 and 191.6 μM, respectively), as well as inhibits migration and increases apoptosis when used at concentrations of 50 and 200 μM. Astilbin (20 mg/kg every other day for 14 days) reduces tumor growth in an MCF-7 mouse xenograft model.

InChI:InChI=1/C21H22O11/c1-7-15(26)17(28)18(29)21(30-7)32-20-16(27)14-12(25)5-9(22)6-13(14)31-19(20)8-2-3-10(23)11(24)4-8/h2-7,15,17-26,28-29H,1H3/t7-,15-,17+,18+,19+,20-,21-/m0/s1

Articles related to TAXIFOLIN 3-O-RHAMNOSIDE:

Article

Source

Cationic zirconocene- or hafnocene-based Lewis acids in organic synthesis: Glycoside-flavonoid analogy

Ohmori, Ken,Hatakeyama, Keisuke,Ohrui, Hiroki,Suzuki, Keisuke

, p. 1365 - 1373 (2007/10/03)

First synthesis of astilbin, biologically active glycosyl flavonoid isolated from Chinese folk medicine

Ohmori, Ken,Ohrui, Hiroki,Suzuki, Keisuke

, p. 5537 - 5541 (2007/10/03)

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