Nebivolol

  • Name: Nebivolol
  • CAS: 99200-09-6
  • Purity: 99%
Inquiry

Details

High quality purity >99% Nebivolol 99200-09-6 for sale

  • Molecular Formula: C22H25F2NO4
  • Molecular Weight: 405.442
  • Appearance/Colour: Odour 
  • Vapor Pressure: 2.88E-15mmHg at 25°C 
  • Refractive Index: 1.58 
  • Boiling Point: 600.455 °C at 760 mmHg 
  • PKA: 14.29±0.20(Predicted) 
  • Flash Point: 316.944 °C 
  • PSA： 70.95000 
  • Density: 1.31 g/cm3 
  • LogP: 2.75450 

Nebivolol(Cas 99200-09-6) Usage

Definition

ChEBI: A member of the class of chromanes that is 2,2'-iminodiethanol in which one hydrogen attached to each hydroxy-bearing carbon is replaced by a 6-fluorochroman-2-yl group.

Brand name

Nebilet

InChI:InChI=1/C22H25F2NO4/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2

99200-09-6 Relevant articles

Preparation method and application of Smo inhibitor based on Nebivolol

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, (2019/10/17)

The invention discloses a preparation me...

A NEW METHOD FOR PRODUCING NEBIVOLOL HYDROCHLORIDE OF HIGH PURITY

-

Page/Page column 22, (2015/09/22)

The invention relates to a process for p...

PREPARATION OF NEBIVOLOL

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Page/Page column 14, (2011/10/19)

Processes for the synthesis of pharmacol...

PROCESS FOR THE PREPARATION OF NEBIVOLOL

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, (2011/09/15)

The present invention relates to a novel...

99200-09-6 Process route

α,α'-[[(phenylmethyl)imino]bismethylene]bis-[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]
929706-85-4

α,α'-[[(phenylmethyl)imino]bismethylene]bis-[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]

nebivolol
99200-09-6,118457-14-0,118457-15-1,119365-25-2,119365-23-0,1360598-84-0

nebivolol

Conditions
Conditions Yield
With hydrogen; palladium on activated charcoal; In 2-methoxy-ethanol; at 20 ℃; normal pressure;
65%
With ammonium formate; palladium 10% on activated carbon; In methanol; for 3h; Reflux;
56.6%
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
99199-90-3,793669-26-8,876514-31-7

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

6-fluoro-3,4-dihydro-α-[[(phenylmethyl)amino]methyl]-2H-1-benzopyran-2-methanol
99199-91-4,129050-27-7

6-fluoro-3,4-dihydro-α-[[(phenylmethyl)amino]methyl]-2H-1-benzopyran-2-methanol

nebivolol
99200-09-6,118457-14-0,118457-15-1,119365-25-2,119365-23-0,1360598-84-0

nebivolol

Conditions
Conditions Yield
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran; 6-fluoro-3,4-dihydro-α-[[(phenylmethyl)amino]methyl]-2H-1-benzopyran-2-methanol; at 100 - 110 ℃; for 8h;
With ammonium formate; palladium 10% on activated carbon; In methanol; water; at 45 - 65 ℃; for 2h;

99200-09-6 Upstream products

  • 682359-63-3
    682359-63-3

    N-[(S,S)-1-hydroxy-2-(6-fluoro-chroman-4-one-2-yl)]-N-[(R,S)-1-hydroxy-2-(6-fiuoro-chroman-4-one-2-yl)]-amine

  • 797054-41-2
    797054-41-2

    N-benzyl-N-[(R,R)-1-hydroxy-2-(6-fluoro-chroman-4-one-2-yl)]-N-[(S,R)-1-hydroxy-2-(6-fluoro-chroman-4-one-2-yl)]-amine

  • 129050-27-7
    129050-27-7

    (S*,R*)-(±)-α-[(benzylamino)methyl](6-fluoro-2-chromanyl)methanol

  • 103-49-1
    103-49-1

    dibenzylamine

99200-09-6 Downstream products

  • 9920-09-6
    9920-09-6

    α,α'-iminobis(methylene)bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] hydrochloride

  • 920299-33-8
    920299-33-8

    (R)-1-((R)-6-Fluoro-chroman-2-yl)-2-[(S)-2-((R)-6-fluoro-chroman-2-yl)-2-hydroxy-ethylamino]-ethanol; hydrochloride

  • 152520-56-4
    152520-56-4

    nebivolol hydrochloride

  • 169293-50-9
    169293-50-9

    nebivolol hydrochloride

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